News and information about basic science that may lead researchers to develop a cure for HIV – studies of the latent viral reservoir, shock and kill approaches, gene therapies, immune modulators therapeutic vaccines, broadly neutralizing antibodies and so on.

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  • Could gold be the key to making gene therapy for HIV, blood disorders more accessible?

    Could gold be the key to making gene therapy for HIV, blood disorders more accessible?  Scientists at Fred Hutchinson Cancer Research Center took a step toward making gene therapy more practical by simplifying the way gene-editing instructions are delivered to cells. Using a gold nanoparticle instead of an inactivated virus, they safely delivered gene-editing tools in lab models of HIV and inherited blood disorders, as reported May 27 in Nature Materials.

    28 May 2019 | Phys.org
  • Attacking persistent HIV reservoirs via a ‘long noncoding’ RNA

    As effective as antiretroviral drugs have been in the treatment of HIV, the virus can still hide out in the body in reservoirs that have proven exceedingly difficult to eradicate. Now researchers at Cornell University have found a new way to attack these HIV reservoirs, and it involves “long noncoding” RNAs (lncRNAs), which don’t produce proteins themselves but instead dial protein-producing genes up or down.

    26 March 2019 | Fierce Biotech
  • Science Issues Concern About HIV Remission Monkey Study

    The journal Science is warning readers that an article it published on a much-hyped potential HIV remission approach didn't include all the facts.

    22 March 2019 | Medscape (requires free registration)
  • A Path to Curing H.I.V.

    The Daily podcast: For only the second time since the start of a global epidemic, a person was reported this month to have been cured of H.I.V., the virus that causes AIDS. Scientists and activists had almost given up on reaching that milestone. Here’s a look at how we got to this point.

    21 March 2019 | New York Times (audio)
  • Curing HIV just got more complicated. Can CRISPR help?

    Antiretroviral (ARV) drugs have turned HIV infection from a death sentence to a chronic condition. In most people the drugs routinely tamp HIV levels so low that standard tests find no virus in blood samples. But inexplicably, in about 10% of infected people HIV remains easily detectable in the blood even though they take their daily pills and are not saddled with drug-resistant mutants of the virus.

    18 March 2019 | Science
  • Italy's therapeutic AIDS vaccine shows drastic reduction of HIV virus reservoirs: study

    Clinical trials of an Italian therapeutic vaccine against AIDS showed a drastic reduction of virus reservoirs in treated patients, Italian researchers said on Wednesday.

    14 March 2019 | Xinhua
  • CROI 2019: Will the “Düsseldorf patient” make three — further propelling cure research?

    Five years after a stem cell transplant with the same critical factor as those received by the Berlin patient and the London patient, and four months after stopping antiretroviral treatment, a Düsseldorf man remains virally suppressed

    12 March 2019 | Science Speaks
  • Anthony Fauci: Physicians cured a man of HIV, but that's not our best shot at fighting AIDS

    The Berlin and London patients give important insights for HIV researchers, and a cure for HIV is an aspiration we continue to pursue. But the end of the epidemic - the reduction of new HIV infections and HIV-related deaths to very low levels - is within our reach even without a cure.

    12 March 2019 | Sydney Morning Herald
  • What You Need to Know About the Second Person Likely Cured of HIV

    Interview with Richard Jefferys, the Basic Science, Vaccines, and Cure Project Director of Treatment Action Group, about the significance of the second person seemingly cured of HIV, what both community members and journalists should know about this study, and how HIV cure research stories in the mainstream press can create false hope for people living with HIV.

    11 March 2019 | The Body Pro
  • When Undetectable Is Unachievable: Study Offers Insights into HIV Persistence

    Rarely, people living with HIV are unable to maintain an undetectable viral load despite strict adherence to daily ART. New NIAID-funded research suggests that this sometimes can occur when a single cell from the HIV reservoir—the population of long-lived HIV-infected cells that ART cannot eradicate—multiplies to create many identical cells that produce enough virus to be detected by standard viral load tests.

    11 March 2019 | National Institute of Allergy and Infectious Diseases
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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